GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.021
Abstract: New targeted therapies are urgently needed to improve the survival of patients with refractory osteosarcoma (OS). In this study, we show that bortezomib (BTZ), not for OS treatment in the clinic, induces endoplasmic reticulum (ER)… read more here.
Keywords: enhances atf4; atf4 induced; inhibition enhances; grp78 inhibition ... See more keywords
Glycogen synthase kinase 3β inhibition enhances Notch1 recycling
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-07-0474
Abstract: The Notch signaling pathway is essential to a variety of processes during development and throughout adulthood. It is demonstrated that GSK3β controls Notch signaling by regulating receptor recycling rates. read more here.
Keywords: kinase inhibition; glycogen synthase; inhibition enhances; synthase kinase ... See more keywords
WEE1 inhibition enhances sensitivity to hypoxia/reoxygenation in HeLa cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrz045
Abstract: Abstract Hypoxia/reoxygenation (H/R) treatment reportedly induces DNA damage response (DDR), including DNA double-strand break (DSB) repair and G2 arrest, resulting in reduction of clonogenic survival. Because WEE1 plays a key role in the G2/M checkpoint… read more here.
Keywords: hypoxia reoxygenation; wee1 inhibition; inhibition; inhibition enhances ... See more keywords
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.01.10.475285
Abstract: Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma – namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies – may offer an improved survival benefit by overcoming limitations associated with any individual therapy. Still,… read more here.
Keywords: presentation; mek inhibition; tumor antigens; tumor ... See more keywords
IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2018-05-850826
Abstract: Proteasome inhibitors (PI) are extensively used for the therapy of multiple myeloma (MM) and mantle cell lymphoma. However, patients continuously relapse or are intrinsically resistant to this class of drugs. Here, to identify targets that… read more here.
Keywords: inhibitor; agi 6780; inhibition; inhibition enhances ... See more keywords
mTOR inhibition enhances efficacy of dasatinib in ABL-rearranged Ph-like B-ALL
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24020
Abstract: High-risk subtypes of B-cell acute lymphoblastic leukemia (B-ALL) include Philadelphia chromosome-positive (Ph+) B-ALL driven by the BCR-ABL1 oncogene and a more recently identified subtype known as BCR-ABL-like or Ph-like B-ALL. A hallmark of both Ph+… read more here.
Keywords: enhances efficacy; mtor inhibition; dasatinib; inhibition enhances ... See more keywords