Abstract 3935: Durable inhibition of ERK phosphorylation is required for tumor regression in novel human and mouse models of NF1-inactivated melanoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3935
Abstract: Inactivating mutations in Neurofibromin 1 (NF1), a RAS-GTPase, have been identified in a significant subset of melanomas, both concurrent with and exclusive of oncogenic BRAF and RAS mutations. However, FDA-approved therapies targeting the MAPK pathway… read more here.
Keywords: nf1 inactivated; braf; inhibition; tumor ... See more keywords
Synthetic chalcone derivatives inhibit cytokine secretion via inhibition of ERK and JNK pathways in human U937 macrophage
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DOI: 10.4314/tjpr.v18i4.11
Abstract: Purpose: To investigate the inhibitory effects of a chalcone derivative on lipopolysaccharide (LPS)induced interleukin (IL)-6 and IL-8 secretions and on LPS-induced mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) activation in human U937… read more here.
Keywords: via inhibition; secretion; inhibition erk; u937 macrophage ... See more keywords