Inhibition of Ferroptosis Attenuates Glutamate Excitotoxicity and Nuclear Autophagy in a CLP Septic Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "SHOCK"
DOI: 10.1097/shk.0000000000001893
Abstract: ABSTRACT Sepsis-associated encephalopathy (SAE) often manifests in severe diffuse cerebral dysfunction due to an aberrant systemic immune response to infection. The underlying pathophysiology of SAE is not entirely understood but is likely a multifactorial process… read more here.
Keywords: nuclear autophagy; inhibition ferroptosis; sae; glutamate excitotoxicity ... See more keywords
Inhibition of Ferroptosis in the Subacute Phase of Ischemic Stroke Worsens Aversive Learning In Diabetic Rats: A Randomized Double-Blind Preclinical Trial
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730079
Abstract: Diabetes increases the risk of hemorrhagic transformation as well as post-stroke cognitive impairment (PCSI). We have shown that iron chelation in the subacute phase improves stroke cognitive outcomes in experimental models of diabetes. We hypothesized… read more here.
Keywords: inhibition ferroptosis; physiology; subacute phase; stroke ... See more keywords