Inhibition of the Fibrillation of Amyloid Aβ1-40 by Hybrid- lipid-Polymer Vesicles.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200522
Abstract: The transformation of functional proteins into amyloidic plaques is responsible for the impairment of neurological functions in patients fallen victim to debilitating neurological conditions like Alzheimer's, Parkinson's and Huntington's diseases. The nucleating role of amyloid… read more here.
Keywords: inhibition fibrillation; fibrillation; amyloid hybrid; hybrid vesicles ... See more keywords
Inhibition of Aβ1-42 fibrillation by chaperonins: human Hsp60 is a stronger inhibitor than its bacterial homologue GroEL.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00183
Abstract: Alzheimer's disease is a chronic neurodegenerative disease characterized by the accumulation of pathological aggregates of amyloid beta peptide. Many efforts have been focused on understanding peptide aggregation pathways and on identification of molecules able to… read more here.
Keywords: aggregation; human hsp60; groel; fibrillation chaperonins ... See more keywords
A resorcinarene for inhibition of Aβ fibrillation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc04854d Click here for additional data file.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.1039/c6sc04854d
Abstract: Low toxic resorcinarene can effectively inhibit Aβ fibrillation and delay the formation of toxic Aβ 42 species. read more here.
Keywords: fibrillation; fibrillation electronic; resorcinarene; inhibition fibrillation ... See more keywords