Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis
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DOI: 10.1073/pnas.2208541120
Abstract: Significance GPR39 is an orphan GPR whose physiological ligand and intracellular pathways in ECs remain poorly characterized. Our data indicate that inhibition of GPR39 protects EC functions by enhancing SHH signaling in aortic ECs. Understanding… read more here.
Keywords: gpr39; hyperglycemia; inhibition gpr39; restores defects ... See more keywords