Inhibition of Human Cholinesterases and In Vitro β-Amyloid Aggregation by Rationally Designed Peptides.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200691
Abstract: The multifactorial nature of Alzheimer’s disease (AD) is now widely recognized, which has increased the interest in compounds that can address more than one AD-associated targets. Herein, we report the inhibitory activity on the human… read more here.
Keywords: cholinesterases vitro; human cholinesterases; aggregation; inhibition human ... See more keywords
Microfouling inhibition of human nosocomial pathogen Pseudomonas aeruginosa using marine cyanobacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2017.11.048
Abstract: Pseudomonas aeruginosa is a Gram negative, opportunistic biofilm forming pathogenic bacterium which is developing as a serious problem worldwide. The pathogenicity of P. aeruginosa mainly depends upon biofilm and quorum sensing (QS) mechanism. Targeting biofilm… read more here.
Keywords: inhibition human; biofilm; microfouling inhibition; pseudomonas aeruginosa ... See more keywords
Nature of Irreversible Inhibition of Human 20S Proteasome by Salinosporamide A. The Critical Role of Lys–Asp Dyad Revealed from Electrostatic Effects Analysis
Sign Up to like & getrecommendations! Published in 2021 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c05313
Abstract: 20S proteasome is the enzymatic core engine involved in the processes of cellular protein regulation, thus becoming a promising target inter alia in the therapy of many diseases. In this work, the ... read more here.
Keywords: nature irreversible; proteasome salinosporamide; inhibition human; 20s proteasome ... See more keywords
Differential Inhibition of Human and Trypanosome Ubiquitin E1S by TAK-243 Offers Possibilities for Parasite Selective Inhibitors
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DOI: 10.1038/s41598-019-52618-3
Abstract: Novel strategies to target Trypanosoma brucei, Trypanosoma cruzi and Leishmania are urgently needed to generate better and safer drugs against Human African Trypanosomiasis, Chagas disease and Leishmaniasis, respectively. Here, we investigated the feasibility of selectively… read more here.
Keywords: tak 243; differential inhibition; inhibition human; human trypanosome ... See more keywords
Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/c9ra09203j
Abstract: Thrombin inhibition therapy is a practical strategy to reduce thrombotic and cardiovascular risks via blocking the formation of blood clots. This study aimed to identify naturally occurring thrombin inhibitors from licorice (one of the most… read more here.
Keywords: inhibition human; constituents licorice; thrombin constituents; inhibition ... See more keywords
In Vitro Inhibition of Human CYP450s 1A2, 2C9, 3A4/5, 2D6 and 2E1 by Grandisin.
Sign Up to like & getrecommendations! Published in 2017 at "Planta medica"
DOI: 10.1055/s-0042-124615
Abstract: Grandisin, a lignan isolated from many species of plants, such as Virola surinamensis, is a potential drug candidate due to its biological properties, highlighted by its antitumor and trypanocidal activities. In this study, the inhibitory… read more here.
Keywords: mechanism based; inhibition human; inhibition; min ... See more keywords
In vitro inhibition of human UGT isoforms by ritonavir and cobicistat
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DOI: 10.1080/00498254.2017.1370655
Abstract: Abstract 1. Ritonavir and cobicistat are pharmacokinetic boosting agents used to increase systemic exposure to other antiretroviral therapies. The manufacturer’s data suggests that cobicistat is a more selective CYP3A4 inhibitor than ritonavir. However, the inhibitory effect… read more here.
Keywords: ritonavir cobicistat; human ugt; ugt isoforms; inhibition human ... See more keywords
Inhibition of Human Monoamine Oxidases A and B by Specialized Metabolites Present in Fresh Common Fruits and Vegetables
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DOI: 10.3390/plants11030346
Abstract: Diets rich in fruits and vegetables are associated with better psychological wellbeing and cognitive functions, although it is unclear which molecules and mechanisms are involved. One potential explanation is the inhibition of monoamine oxidases (MAOs),… read more here.
Keywords: inhibition human; monoamine oxidases; human monoamine; fruits vegetables ... See more keywords
Inhibition of Human Immunodeficiency Virus Type 1 Entry by a Keggin Polyoxometalate
Sign Up to like & getrecommendations! Published in 2018 at "Viruses"
DOI: 10.3390/v10050265
Abstract: Here, we report the anti-human immunodeficiency virus (HIV) potency and underlying mechanisms of a Keggin polyoxometalate (PT-1, K6HPTi2W10O40). Our findings showed that PT-1 exhibited highly potent effects against a diverse group of HIV type 1… read more here.
Keywords: human immunodeficiency; inhibition human; immunodeficiency virus; virus ... See more keywords