Substoichiometric Inhibition of Insulin against IAPP Aggregation Is Attenuated by the Incompletely Processed N-Terminus of proIAPP.
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DOI: 10.1021/acschemneuro.2c00231
Abstract: Substoichiometric aggregation inhibition of human islet amyloid polypeptide (IAPP), the hallmark of type 2 diabetes impacting millions of people, is crucial for developing clinic therapies, yet it remains challenging given that many candidate inhibitors require… read more here.
Keywords: aggregation; substoichiometric inhibition; inhibition; iapp ... See more keywords