Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
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DOI: 10.1002/advs.202104469
Abstract: Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists. The available therapies for tendinopathy are limited in number and efficacy and… read more here.
Keywords: inhibition integrin; activation tgf; tgf; activation ... See more keywords
Selective inhibition of integrin αvβ6 leads to rapid induction of urinary bladder tumors in cynomolgus macaques
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DOI: 10.1093/toxsci/kfac128
Abstract: Abstract Administration of a novel and selective small molecule integrin αvβ6 inhibitor, MORF-627, to young cynomolgus monkeys for 28 days resulted in the rapid induction of epithelial proliferative changes in the urinary bladder of 2 animals,… read more here.
Keywords: bladder; integrin; rapid induction; inhibition integrin ... See more keywords