Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
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DOI: 10.1016/j.celrep.2018.11.043
Abstract: Summary Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). We report that syrosingopine, an anti-hypertensive drug, is a dual… read more here.
Keywords: inhibition lactate; cancer cells; cancer; mct1 mct4 ... See more keywords