Gefitinib Inhibits Invasion and Metastasis of Osteosarcoma via Inhibition of Macrophage Receptor Interacting Serine-Threonine Kinase 2
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DOI: 10.1158/1535-7163.mct-19-0903
Abstract: Most patients with osteosarcoma have subclinical pulmonary micrometastases at diagnosis. Mounting evidence suggests that macrophages facilitate metastasis. As the EGFR has been implicated in carcinoma–macrophage cross-talk, in this study, we asked whether gefitinib, an EGFR… read more here.
Keywords: macrophage; inhibition macrophage; invasion; macrophage receptor ... See more keywords
Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma
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DOI: 10.3390/ijms24054719
Abstract: Chitotriosidase (CHIT1) is an enzyme produced by macrophages that regulates their differentiation and polarization. Lung macrophages have been implicated in asthma development; therefore, we asked whether pharmacological inhibition of macrophage-specific CHIT1 would have beneficial effects… read more here.
Keywords: chit1; macrophage specific; airway remodeling; inhibition macrophage ... See more keywords