The balance between induction and inhibition of mevalonate pathway regulates cancer suppression by statins: A review of molecular mechanisms.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.06.026
Abstract: Statins are widely used drugs for their role in decreasing cholesterol in hypercholesterolemic patients. Statins through inhibition of Hydroxy Methyl Glutaryl-CoA Reductase (HMGCR), the main enzyme of the cholesterol biosynthesis pathway, inhibit mevalonate pathway that… read more here.
Keywords: cancer developing; inhibition mevalonate; mevalonate pathway; mevalonate isoprenoid ... See more keywords
Inhibition of mevalonate pathway prevents ischemia‐induced cardiac dysfunction in rats via RhoA‐independent signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Therapeutics"
DOI: 10.1111/1755-5922.12285
Abstract: AIM We previously demonstrated that anoxia-mediated Ca2+ handling dysfunction could be ameliorated through inhibition of mevalonate pathway via RhoA- and Ras-related mechanisms in H9c2 cells. In this study, we further explored whether inhibition of mevalonate… read more here.
Keywords: mevalonate pathway; dysfunction; cardiac dysfunction; inhibition mevalonate ... See more keywords