Pharmacological inhibition of the Notch pathway enhances the efficacy of androgen deprivation therapy for prostate cancer
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DOI: 10.1002/ijc.31346
Abstract: Although androgen deprivation therapy (ADT) is a standard treatment for metastatic prostate cancer, this disease inevitably recurs and progresses to ADT‐resistant stage after this therapy. Accordingly, understanding the mechanism of resistance to ADT and finding… read more here.
Keywords: notch; inhibition notch; notch pathway; therapy ... See more keywords
Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors
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DOI: 10.2337/db16-1587
Abstract: Inhibition of notch signaling is known to induce differentiation of endocrine cells in zebrafish and mouse. After performing an unbiased in vivo screen of ∼2,200 small molecules in zebrafish, we identified an inhibitor of Cdk5… read more here.
Keywords: inhibition notch; differentiation; cell differentiation; cdk5 ... See more keywords