Inhibition of the Notch1 pathway induces peripartum cardiomyopathy
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DOI: 10.1111/jcmm.15423
Abstract: Increased expression and activity of cardiac and circulating cathepsin D and soluble fms‐like tyrosine kinase‐1 (sFlt‐1) have been demonstrated to induce and promote peripartum cardiomyopathy (PPCM) via promoting cleavage of 23‐kD prolactin (PRL) to 16‐kD… read more here.
Keywords: inhibition notch1; peripartum cardiomyopathy; notch1 pathway; inhibition ... See more keywords
Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 Signaling
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DOI: 10.1159/000485890
Abstract: Background: Notch1 has been linked to the pathogenesis of asthma due to its contribution on Th1/Th2 imbalance. γ-Secretase inhibitor (GSI) acts as an effective blocker of Notch1 signaling. Glucocorticoids (GCs) are the most effective anti-inflammatory… read more here.
Keywords: inhibition notch1; notch1 signaling; dex gsi; th1 th2 ... See more keywords