Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARĪ³ activation exerting cancer growth suppression
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.02.015
Abstract: Background c-Src is a driver oncogene well-known for tumorigenic signaling, but little for metabolic function. Previous reports about c-Src regulation of glucose metabolism prompted us to investigate its function in other nutrient modulation, particularly in… read more here.
Keywords: inhibition oncogenic; lipolysis; src; cancer ... See more keywords
Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance
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DOI: 10.1158/2159-8290.cd-21-1661
Abstract: Mutational scanning in base-edited IDH-mutant leukemia cells uncovered recurrent mutations that disable uncompetitive inhibition, which reveals a new class of pathogenic mutations and mechanisms for resistance to IDH-targeting therapies. read more here.
Keywords: inhibition; disabling uncompetitive; uncompetitive inhibition; inhibition oncogenic ... See more keywords