Dipeptidyl Peptidase-4 Inhibition Prevents Vascular Calcification by Potentiating the Insulin-Like Growth Factor-1 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "JACC: Basic to Translational Science"
DOI: 10.1016/j.jacbts.2018.11.002
Abstract: Cardiovascular calcification is a growing burden and a leading contributor to acute cardiovascular events, but no therapeutics are currently available. Recently, Choi et al. [(1)][1] put forward dipeptidyl peptidase (DPP)-4 as a new pharmacological target to… read more here.
Keywords: peptidase inhibition; inhibition prevents; calcification; prevents vascular ... See more keywords
BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz114
Abstract: Cell culture K562 cells were acquired from ATCC and maintained in Isocove’s Modified Dulbecco’s Media (IMDM) (Life Technologies) containing 10% fetal bovine serum. Adherent STAG2null lines were detached for subculture using trypsin-EDTA (0.005% final concentration,… read more here.
Keywords: erg transcription; inhibition prevents; bet inhibition; prevents aberrant ... See more keywords
Response to Comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adh0604
Abstract: We have replicated our original finding of elevated cleaved caspase-1 in mouse brains and neuroprotection by an NLRP3 inflammasome inhibitor in two mouse models of Parkinson’s disease. Description We have replicated our original finding of… read more here.
Keywords: inhibition prevents; response comment; mouse; pathology ... See more keywords