The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102813
Abstract: Background Preeclampsia is a devastating hypertensive disorder of pregnancy with unknown mechanism. Recent studies have considered abnormal autophagy as a new cellular mechanism for this disorder, while little is known about how autophagy is specifically… read more here.
Keywords: pkc inhibition; inhibition; pathogenesis; preeclampsia ... See more keywords
Allosteric regulation and inhibition of protein kinases.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20220940
Abstract: The human genome encodes more than 500 different protein kinases: signaling enzymes with tightly regulated activity. Enzymatic activity within the conserved kinase domain is influenced by numerous regulatory inputs including the binding of regulatory domains,… read more here.
Keywords: allosteric regulation; protein kinases; inhibition protein; protein ... See more keywords
Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-4731
Abstract: Mutations in RNA splicing factors commonly occur in myeloid leukemia and solid tumors. These mutations occur in a heterozygous manner and confer dependency on the wild-type allele. Studies have shown that splicing factor mutant cancers… read more here.
Keywords: protein arginine; therapeutic targeting; inhibition protein; targeting rna ... See more keywords
Implications of Axis Inhibition Protein 2 in Breast Cancer Progression
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DOI: 10.21873/invivo.13122
Abstract: Background/Aim: Although axis inhibition protein 2 (Axin2) has been reported to act as a tumour suppressor, recent findings suggest that it exhibits oncogenic effects by mediating Snail1-induced epithelial-mesenchymal transition (EMT) in breast cancer cells. EMT… read more here.
Keywords: progression; inhibition protein; breast cancer; axis inhibition ... See more keywords