IL-1β Inhibition Reduces Atherosclerotic Inflammation in HIV Infection.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.09.038
Abstract: People living with HIV are at increased risk of cardiovascular disease (CVD) [(1)][1]. Arterial inflammation is heightened in HIV infection, which may explain the high burden of CVD [(2)][2]. Recently, the CANTOS (Cardiovascular Risk Reduction… read more here.
Keywords: hiv infection; inhibition reduces; hiv; inflammation ... See more keywords
CA2 inhibition reduces the precision of hippocampal assembly reactivation
Sign Up to like & getrecommendations! Published in 2021 at "Neuron"
DOI: 10.1016/j.neuron.2021.08.034
Abstract: The structured reactivation of hippocampal neuronal ensembles during fast synchronous oscillatory events, termed sharp-wave ripples (SWRs), has been suggested to play a crucial role in the storage and use of memory. Activity in both the… read more here.
Keywords: inhibition reduces; reactivation; ca2; ca2 inhibition ... See more keywords
Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01238-5
Abstract: In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The adenosine A 2A receptors (A 2A Rs), modulators… read more here.
Keywords: fmr1 mice; inhibition reduces; receptor inhibition; adenosine a2a ... See more keywords
Sodium‐glucose cotransporter‐2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body‐induced NRF2 activation
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.1111/dom.14503
Abstract: To evaluate whether sodium‐glucose cotransporter‐2 (SGLT2) inhibition reduces cellular senescence in the kidney and to investigate the molecular pathways involved in the renoprotective effect. read more here.
Keywords: inhibition reduces; reduces cellular; sodium glucose; cellular senescence ... See more keywords
NLRP3 Inhibition Reduces rt-PA Induced Endothelial Dysfunction under Ischemic Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040762
Abstract: Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a mainstay of acute ischemic stroke treatment but is associated with bleeding complications, especially after prolonged large vessel occlusion. Recently, inhibition of the NLRP3 inflammasome led to… read more here.
Keywords: bbb; inhibition; inhibition reduces; nlrp3 inhibition ... See more keywords