Inhibition of SARS-CoV-2 Omicron BA.1 and BA.4 Variants After Fourth Vaccination or Tixagevimab and Cilgavimab Administration in Patients With Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.4226
Abstract: This cohort study assesses the capacity of passive immunization and tixagevimab and cilgavimab to inhibit interaction between receptor-binding domains and angiotensin-converting enzyme 2 in patients with hemato-oncologic diseases. read more here.
Keywords: tixagevimab; inhibition sars; tixagevimab cilgavimab; omicron variants ... See more keywords
Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols
Sign Up to like & getrecommendations! Published in 2021 at "Food Chemistry"
DOI: 10.1016/j.foodchem.2021.131594
Abstract: The abundance of polyphenols in edible plants makes them an important component of human nutrition. Considering the ongoing COVID-19 pandemic, a number of studies have investigated polyphenols as bioactive constituents. We applied in-silico molecular docking… read more here.
Keywords: inhibition sars; protease; cov 3clpro; plant polyphenols ... See more keywords
Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00120
Abstract: Enzymes involved in RNA capping of SARS-CoV-2 are essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity, making them attractive targets for antiviral agents. In this work, we… read more here.
Keywords: nsp14 methyltransferase; inhibition sars; cov nsp14; sars cov ... See more keywords
Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs
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DOI: 10.1093/nar/gkab1096
Abstract: Abstract Circular RNAs (circRNAs) are noncoding RNAs that exist in all eukaryotes investigated and are derived from back-splicing of certain pre-mRNA exons. Here, we report the application of artificial circRNAs designed to act as antisense-RNAs.… read more here.
Keywords: sars cov; proliferation; antisense circrnas; circrnas ... See more keywords
Identification of Darunavir Derivatives for Inhibition of SARS-CoV-2 3CLpro
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DOI: 10.3390/ijms232416011
Abstract: The effective antiviral agents that treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed around the world. The 3C-like protease (3CLpro) of SARS-CoV-2 plays a pivotal role in virus replication; it also has… read more here.
Keywords: derivatives inhibition; cov 3clpro; identification darunavir; inhibition sars ... See more keywords