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   Articles with "inhibition studies" as a keyword



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The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: the case of aldose reductase

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recommendations! Published in 2017 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2017.1363744

Abstract: Abstract Aldose reductase (AR) is an enzyme devoted to cell detoxification and at the same time is strongly involved in the aetiology of secondary diabetic complications and the amplification of inflammatory phenomena. AR is subjected… read more here.

Keywords: aldose reductase; inhibition studies; inhibition; enzyme inhibition ... See more keywords
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Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae

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recommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2021.1929202

Abstract: Abstract The bacterial pathogen Neisseria gonorrhoeae encodes for an α-class carbonic anhydrase (CA, EC 4.2.1.1), NgCA, which was investigated for its inhibition with a series of inorganic and organic anions. Perchlorate and hexafluorophosphate did not… read more here.

Keywords: anion inhibition; studies carbonic; inhibition studies; carbonic anhydrases ... See more keywords
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Inhibition studies of bacterial α-carbonic anhydrases with phenols

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recommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2022.2038592

Abstract: Abstract The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by a panel of phenols and phenolic acids. Mono-, di- and… read more here.

Keywords: inhibition; carbonic anhydrases; anhydrases phenols; bacterial carbonic ... See more keywords
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The mechanism of action of Lactoferrin - Nucleoside Diphosphate Kinase complex in combating biofilm formation.

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recommendations! Published in 2022 at "Protein and peptide letters"

DOI: 10.2174/0929866529666220816160517

Abstract: BACKGROUND The ESKAPE group of pathogens which comprise of multidrug resistant bacteria, namely Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species are the cause of deadly nosocomial infections all over… read more here.

Keywords: kinase; nucleoside diphosphate; inhibition studies; biofilm ... See more keywords
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Mycobacterium tuberculosisβ-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs

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recommendations! Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms20205153

Abstract: The genome of Mycobacterium tuberculosis (Mtb) encodes three β-carbonic anhydrases (CAs, EC 4.2.1.1) that are crucial for the life cycle of the bacterium. The Mtb β-CAs have been cloned and characterized, and the catalytic activities… read more here.

Keywords: inhibition studies; carbonic anhydrases; pathogenic bacteria; tuberculosis ... See more keywords
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Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni, a Platyhelminth Parasite Responsible for Schistosomiasis

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recommendations! Published in 2020 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms21051842

Abstract: Schistosomiasis is a debilitating infection provoked by parasitic flatworms called schistosomes. The species Schistosoma mansoni is endemic in Africa, where it causes intestinal schistosomiasis. Recently, an α-carbonic anhydrase (CA, EC 4.2.1.1) was cloned and characterized… read more here.

Keywords: schistosomiasis; carbonic anhydrase; inhibition studies; sulfonamide inhibition ... See more keywords
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Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors.

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recommendations! Published in 2017 at "Future medicinal chemistry"

DOI: 10.4155/fmc-2017-0074

Abstract: AIM DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activity in… read more here.

Keywords: maleimide derivatives; inhibition studies; dna methyltransferases; non nucleoside ... See more keywords