Structural mechanisms for VMAT2 inhibition by tetrabenazine
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DOI: 10.7554/elife.91973
Abstract: The vesicular monoamine transporter 2 (VMAT2) is a proton-dependent antiporter responsible for loading monoamine neurotransmitters into synaptic vesicles. Dysregulation of VMAT2 can lead to several neuropsychiatric disorders including Parkinson’s disease and schizophrenia. Furthermore, drugs such… read more here.
Keywords: vmat2 inhibition; inhibition tetrabenazine; structural mechanisms; inhibition ... See more keywords