Thrown for a Loop: Awakening BORIS to Evade ALK Inhibition Therapy.
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DOI: 10.1016/j.ccell.2019.09.009
Abstract: Mechanisms of acquired resistance to ALK inhibition therapy in neuroblastoma have not yet been elucidated. In a recent issue of Nature, Debruyne et al. demonstrate that resistant MYCN-amplified ALK-mutated neuroblastoma cells overexpress BORIS, resulting in wide-ranging… read more here.
Keywords: alk inhibition; thrown loop; inhibition therapy; alk ... See more keywords
Cortical Reorganization Following Psychoeducational Counselling and Residual Inhibition Therapy (RIT) in Individuals with Tinnitus
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DOI: 10.1055/s-0042-1743287
Abstract: Introduction Psychoeducational counselling and residual inhibition therapy (RIT) are traditional approaches used in many clinics to manage tinnitus. However, neurophysiological studies to evaluate posttreatment perceptual and functional cortical changes in humans are scarce. Objectives The… read more here.
Keywords: therapy rit; counselling residual; residual inhibition; inhibition therapy ... See more keywords
Pathophysiology of large vessel vasculitis and utility of interleukin-6 inhibition therapy
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DOI: 10.1080/14397595.2018.1546358
Abstract: Abstract Takayasu arteritis (TAK) and giant cell arteritis (GCA) affect mainly large- and medium-sized arteries. In refractory cases, vascular remodeling progresses and leads to serious outcomes. Studies have demonstrated that cytokines such as interleukin (IL)-6… read more here.
Keywords: inhibition therapy; pathophysiology large; vessel vasculitis; therapy ... See more keywords
Cardiac Complications in Immune Checkpoint Inhibition Therapy
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DOI: 10.3389/fcvm.2019.00003
Abstract: Immune checkpoint inhibitors (ICIs) have changed the treatment landscape of advanced cancers. Unfortunately, these agents can induce a wide spectrum of immune-related adverse events (irAEs) through activation of immune responses in non-target organs, including the… read more here.
Keywords: immune checkpoint; inhibition therapy; checkpoint inhibition; complications immune ... See more keywords