Risperidone attenuates acetic acid-induced colitis in rats through inhibition of TLR4/NF-kB signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2020.1808987
Abstract: Abstract Aim The purpose of the present study is to explore the anti-inflammatory potential of risperidone in acetic acid-induced rat colitis through inhibition of TLR4/NF-kB pathway. Methods Acute colitis induction was done by intra-rectal administration… read more here.
Keywords: acid induced; inhibition tlr4; colitis; risperidone ... See more keywords
Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12081999
Abstract: Multiple myeloma (MM) is a B-cell malignancy requiring inflammatory microenvironment signals for cell survival and proliferation. Despite improvements in pharmacological tools, MM remains incurable mainly because of drug resistance. The present study aimed to investigate… read more here.
Keywords: mitochondrial fitness; myeloma; inhibition tlr4; resistance ... See more keywords
Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2016.6097
Abstract: Oxidative stress leads to dysfunction in pancreatic cells, causing a reduction in insulin secretion following exposure to glucose. Toll-like receptor 4 (TLR4) may be activated by exposure to lipopolysaccharide (LPS) stress. TLR4 may mediate the initiation… read more here.
Keywords: dysfunction; inhibition tlr4; rat islets; tlr4 ... See more keywords