Modeling Kinase Inhibition Using Highly Confident Data Sets
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00729
Abstract: Protein kinases form a consistent class of promising drug targets, and several efforts have been made to predict the activities of small molecules against a representative part of the kinome. This study continues our previous… read more here.
Keywords: kinase inhibition; modeling kinase; using highly; kinase ... See more keywords
In vivo morphological alterations of TAMs during KCa3.1 inhibition—by using in vivo two-photon time-lapse technology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1002487
Abstract: Tumor associated macrophages (TAMs) are the mostprevalent cells recruited in the tumor microenvironment (TME). Once recruited, TAMs acquire a pro-tumor phenotype characterized by a typical morphology: ameboid in the tumor core and with larger soma… read more here.
Keywords: two photon; tumor; kca3 inhibition; inhibition using ... See more keywords
Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand
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DOI: 10.3390/plants11030294
Abstract: Thailand has vast areas of tropical forests with many indigenous plants, but limited information is available on their phytochemical profile and in vitro inhibitions of enzymatic and nonenzymatic reactions. This study investigated phenolic profiles using… read more here.
Keywords: drying processes; extract concentration; using extract; indigenous plants ... See more keywords
Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2016.3792
Abstract: MET is expressed on neuroblastoma cells and may trigger tumor growth, neoangiogenesis and metastasis. MET upregulation further represents an escape mechanism to various anticancer treatments including VEGF signaling inhibitors. We developed in vitro a resistance model… read more here.
Keywords: vegfr inhibition; pan vegfr; using cabozantinib; inhibition ... See more keywords