Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception
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DOI: 10.1021/acscentsci.8b00239
Abstract: Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biology,… read more here.
Keywords: via catalytic; inhibition; glucuronidase inhibition; microbial glucuronidase ... See more keywords
BCL6 BTB‐specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12438
Abstract: The BTB domain of B‐cell lymphoma 6 (BCL6) protein was identified as a therapeutic target for B‐cell lymphoma. This study compared the pharmacokinetics (PK) of the BCL6 BTB inhibitor (FX1) between mice and macaques, as… read more here.
Keywords: btb; specific inhibition; bcl6 btb; btb specific ... See more keywords