Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway
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DOI: 10.3390/biom12111574
Abstract: Cardiac fibrosis is an important pathological process in many diseases. Wdr5 catalyzes the trimethylation of lysine K4 on histone H3. The effects of Wdr5 on the cardiac fibrosis phenotype and the activation or transformation of… read more here.
Keywords: wdr5; inhibition wdr5; cardiac fibrosis; cardiac fibroblasts ... See more keywords