Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
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DOI: 10.1021/acschemneuro.8b00600
Abstract: Disease-modifying therapies are needed for Fragile X Syndrome (FXS), as at present there are no effective treatments or cures. Herein, we report on a tetrahydroquinoline-based selective histone deacetylase 6 (HDAC6) inhibitor SW-100, its pharmacological and… read more here.
Keywords: deacetylase; fragile syndrome; histone deacetylase; inhibitor 100 ... See more keywords