HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve
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DOI: 10.3389/fcvm.2022.1002067
Abstract: HIF1A is significantly upregulated in calcified human aortic valves (AVs). Furthermore, HIF1A inhibitor PX-478 was shown to inhibit AV calcification under static and disturbed flow conditions. Since elevated stretch is one of the major mechanical… read more here.
Keywords: calcification; stretch; inhibitor 478; collagen turnover ... See more keywords