Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer
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DOI: 10.1007/s10637-018-0663-0
Abstract: SummaryOverexpression and cellular mis-localization of aurora kinase A (AURKA) in gastrointestinal cancers results in chromosomal instability, activation of multiple oncogenic pathways, and inhibition of pro-apoptotic signaling. Inhibition of AURKA causes mitotic delays, severe chromosome congression, and… read more here.
Keywords: study; aurora kinase; inhibitor alisertib;