Articles with "inhibitor apoptosis" as a keyword



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1H, 13C and 15N resonance assignments of the first BIR domain of cellular inhibitor of apoptosis protein 1.

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Published in 2022 at "Biomolecular NMR assignments"

DOI: 10.1007/s12104-022-10065-8

Abstract: Cellular inhibitor of apoptosis protein-1 (cIAP-1) is member of inhibitor of apoptosis proteins (IAPs) which can affect apoptosis through interactions with caspases. cIAP-1 is a multi-domain protein and able to regulate apoptosis through interactions with… read more here.

Keywords: inhibitor apoptosis; apoptosis; domain; bir ... See more keywords
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Tumor Distribution by Quantitative Mass Spectrometry Imaging of the Inhibitor of Apoptosis Protein Antagonist Xevinapant in Patients with Resectable Squamous Cell Carcinoma of the Head and Neck (EudraCT Number: 2014-004655-31).

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Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c00943

Abstract: As tumors are very heterogeneous, investigating the penetration and concentration of an anticancer drug in different histological regions of a tumor is key to evaluate the efficacy, to improve the pharmacokinetics/pharmacodynamics (PK/PD) relationship evaluation, and… read more here.

Keywords: spectrometry imaging; inhibitor apoptosis; mass spectrometry; quantitative mass ... See more keywords
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Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.

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Published in 2023 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.3c00467

Abstract: We have recently reported on the use of aryl-fluorosulfates in designing water- and plasma-stable agents that covalently target Lys, Tyr, or His residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP)… read more here.

Keywords: inhibitor apoptosis; lys covalent; protein iap; apoptosis protein ... See more keywords
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Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.

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Published in 2019 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b01668

Abstract: Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of cancer cells. Inhibitor of apoptosis proteins (IAPs)… read more here.

Keywords: iap antagonists; apoptosis; protein iap; apoptosis protein ... See more keywords
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A Novel X-Linked Inhibitor of Apoptosis Deficient Variant Showing Attenuated Epstein-Barr Virus Response.

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Published in 2020 at "Journal of the Pediatric Infectious Diseases Society"

DOI: 10.1093/jpids/piaa048

Abstract: We report on 2 Asian siblings with X-linked inhibitor of apoptosis deficiency that arose from a novel deletion that presented with Epstein-Barr virus disease and hemophagocytic lymphohistiocytosis. This disease is ascribed to dysfunction in the… read more here.

Keywords: epstein barr; linked inhibitor; novel linked; barr virus ... See more keywords
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Isobaric tags for relative and absolute quantitation-based quantitative proteomic analysis of X-linked inhibitor of apoptosis and H2AX in etoposide-induced renal cell carcinoma apoptosis

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Published in 2019 at "Chinese Medical Journal"

DOI: 10.1097/cm9.0000000000000553

Abstract: Abstract Background: X-linked inhibitor of apoptosis (XIAP) is a vital factor in the anti-apoptosis mechanism of tumors and is highly expressed in renal cell carcinoma (RCC). However, the mechanism through which XIAP regulates DNA damage… read more here.

Keywords: inhibitor apoptosis; renal cell; cell carcinoma; linked inhibitor ... See more keywords
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Inhibition of IAP (inhibitor of apoptosis) proteins represses inflammatory status via nuclear factor‐kappa B pathway in murine endometriosis lesions

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Published in 2018 at "American Journal of Reproductive Immunology"

DOI: 10.1111/aji.12780

Abstract: How is the role of inhibitor of apoptosis proteins (IAPs) in the development of murine endometriosis lesions? read more here.

Keywords: apoptosis proteins; murine endometriosis; endometriosis lesions; inhibitor apoptosis ... See more keywords
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Unique BIR domain sets determine inhibitor of apoptosis protein–driven cell death and NOD2 complex signal specificity

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Published in 2018 at "Science Signaling"

DOI: 10.1126/scisignal.aao3964

Abstract: The unique positioning of similar domains determines the signaling specificity of IAP family proteins. Structure-function specificity of IAP proteins Inhibitor of apoptosis proteins (IAPs) are involved in regulating cell death and inflammation. As such, both… read more here.

Keywords: protein; apoptosis; apoptosis protein; cell death ... See more keywords
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Inhibitor of apoptosis proteins (IAP) antagonist induces T-cell proliferation after cross-presentation by dendritic cells.

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Published in 2023 at "Cancer immunology research"

DOI: 10.1158/2326-6066.cir-22-0494

Abstract: Cross-presentation of tumor antigens by dendritic cells (DCs) is crucial to prime, stimulate and restimulate CD8+ T cells. This process is important in initiating and maintaining an antitumor response. Here, we show that the presence… read more here.

Keywords: inhibitor apoptosis; cell proliferation; presentation; cross presentation ... See more keywords
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Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer

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Published in 2023 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2023.1124600

Abstract: Evasion from apoptosis is a hallmark of cancer. Inhibitor of apoptosis proteins (IAPs) contribute to this hallmark by suppressing the induction of cell death. IAPs were found to be overexpressed in cancerous tissues and to… read more here.

Keywords: inhibitor apoptosis; apoptosis; targets bladder; apoptosis proteins ... See more keywords
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A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer

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Published in 2022 at "Cancers"

DOI: 10.3390/cancers14071671

Abstract: Simple Summary The Inhibitor of Apoptosis (IAP) family of proteins has emerged as a potential pharmacological target in cancer. Abnormal expression of IAPs can lead to dysregulated cell suicide, promoting the development of different pathologies.… read more here.

Keywords: inhibitor apoptosis; review current; impact; apoptosis proteins ... See more keywords