O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
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DOI: 10.1021/acschemneuro.2c00057
Abstract: Neurodegenerative proteinopathies are characterized by the intracellular formation of insoluble and toxic protein aggregates in the brain that are closely linked to disease progression. In Alzheimer's disease and in rare tauopathies, aggregation of the microtubule-associated… read more here.
Keywords: inhibitor asn90; pathology; tau synuclein; synuclein ... See more keywords