Clinical and Morphologic Characteristics of Fibroblast Growth Factor Receptor Inhibitor-Associated Retinopathy.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2021.3331
Abstract: Importance Fibroblast growth factor receptor (FGFR) 1 to 4 inhibitors are approved by the US Food and Drug Administration and suppress the mitogen-activated protein kinase (MAPK) pathway, with a potential for treatment-related retinopathy. To date,… read more here.
Keywords: iqr; inhibitor associated; fluid; fgfr inhibitors ... See more keywords
Neuromuscular Complications of Programmed Cell Death-1 (PD-1) Inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-018-0878-7
Abstract: Purpose of ReviewIn recent years, immune checkpoint inhibitors have been increasingly used in patients with metastatic cancers with favorable oncological outcomes; however, there have also been increasing number of cancer survivors who have developed immune-related… read more here.
Keywords: inhibitor; inhibitor associated; neuromuscular complications; associated neuromuscular ... See more keywords
PD-1 and PD-L1 expression in PD-1 Inhibitor-Associated Colitis and Its Mimics.
Sign Up to like & getrecommendations! Published in 2020 at "Histopathology"
DOI: 10.1111/his.14115
Abstract: AIMS Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced malignancies by boosting immune-mediated destruction of neoplastic cells, but course with side effects stemming from generalized immune system activation against normal tissues. Checkpoint ligand… read more here.
Keywords: inhibitor associated; colitis; associated colitis; expression ... See more keywords
Recommendations for standardizing biopsy acquisition and histological assessment of immune checkpoint inhibitor-associated colitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004560
Abstract: Immune checkpoint inhibitor-associated colitis (ICIC) affects approximately 15% of cancer patients treated with immunotherapy. Although histological evaluation is potentially valuable for both the diagnosis of ICIC and evaluation of disease activity, use in clinical practice… read more here.
Keywords: associated colitis; checkpoint inhibitor; immune checkpoint; inhibitor associated ... See more keywords
A Case of Non-Resolving MEK Inhibitor-Associated Retinopathy
Sign Up to like & getrecommendations! Published in 2019 at "Case Reports in Ophthalmology"
DOI: 10.1159/000503414
Abstract: The mitogen-activated kinase pathway plays an important role in cell survival, and its dysregulation is associated with cancers such as melanoma. Drugs designed to target this pathway have been associated with serous retinal detachments in… read more here.
Keywords: case non; inhibitor; mek inhibitor; inhibitor associated ... See more keywords
Choroidal vasculature analysis in MEK inhibitor-associated retinopathy.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of ophthalmology"
DOI: 10.1177/11206721221081471
Abstract: PURPOSE To evaluate choroidal vascularity index (CVI) in patients developing mitogen-activated protein kinase kinase (MEK) inhibitor-associated retinopathy (MEKAR). METHODS In this prospective observational study, extensive ophthalmic examination was performed, including enhanced-depth-imaging-optical coherence tomography (EDI-OCT). EDI-OCT… read more here.
Keywords: inhibitor associated; analysis; associated retinopathy; mek inhibitor ... See more keywords
Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2019070676
Abstract: BACKGROUND Despite increasing recognition of the importance of immune checkpoint inhibitor-associated AKI, data on this complication of immunotherapy are sparse. METHODS We conducted a multicenter study of 138 patients with immune checkpoint inhibitor-associated AKI, defined… read more here.
Keywords: inhibitor associated; checkpoint inhibitor; associated aki; immune checkpoint ... See more keywords
Angiotensin-Converting Enzyme Inhibitor– Associated Angioedema: From Bed to Bench
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Investigational Allergology and Clinical Immunology"
DOI: 10.18176/jiaci.0458
Abstract: BACKGROUND AND OBJECTIVE Angiotensin-converting enzyme inhibitor-associated angioedema (ACEI-AAE) affects 0.1%-0.7% of patients treated with ACEIs. While previous research suggests that angioedema attacks result from increased vascular permeability, the pathogenesis is not completely understood. Objective: This… read more here.
Keywords: inhibitor associated; enzyme inhibitor; converting enzyme; angiotensin converting ... See more keywords
DPP-4 Inhibitor-associated Bullous Pemphigoid in a Hemodialysis Patient
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.3461-19
Abstract: An 85-year-old man complained of a rash on his upper limbs, chest wall and back (Picture). He had been undergoing hemodialysis due to end-stage diabetic kidney disease and taking vildagliptin [dipeptidyl peptidase-4 inhibitor (DPP4i)] for… read more here.
Keywords: hemodialysis; inhibitor associated; bullous pemphigoid; dpp inhibitor ... See more keywords
Risk Factors and Characteristics of Checkpoint Inhibitor-Associated Autoimmune Diabetes Mellitus (CIADM): A Systematic Review and Delineation From Type 1 Diabetes.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes care"
DOI: 10.2337/dc22-2202
Abstract: BACKGROUND Checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM) is a distinct form of autoimmune diabetes that is a rare complication of immune checkpoint inhibitor therapy. Data regarding CIADM are limited. PURPOSE To systematically review available evidence… read more here.
Keywords: checkpoint inhibitor; autoimmune diabetes; associated autoimmune; diabetes mellitus ... See more keywords
Aromatase Inhibitor-Associated Musculoskeletal Syndrome: Understanding Mechanisms and Management
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.713700
Abstract: Aromatase inhibitors (AIs) are a key component in the chemoprevention and treatment of hormone receptor-positive (HR+) breast cancer. While the addition of AI therapy has improved cancer-related outcomes in the management of HR+ breast cancer,… read more here.
Keywords: aromatase inhibitor; musculoskeletal syndrome; inhibitor associated; management ... See more keywords