Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain.
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DOI: 10.1016/j.joca.2016.09.006
Abstract: OBJECTIVE Autotaxin is a secreted lysophospholipase that mediates the conversion of lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA), a bioactive lipid mediator. Autotaxin levels in plasma and synovial fluid correlate with disease severity in patients… read more here.
Keywords: inhibitor; autotaxin; joint pain; inhibitor autotaxin ... See more keywords