An allosteric inhibitor of bacterial Hsp70 chaperone potentiates antibiotics and mitigates resistance.
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DOI: 10.1016/j.chembiol.2021.11.004
Abstract: DnaK is the bacterial homolog of Hsp70, an ATP-dependent chaperone that helps cofactor proteins to catalyze nascent protein folding and salvage misfolded proteins. In the pathogen Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), DnaK… read more here.
Keywords: bacterial hsp70; allosteric inhibitor; inhibitor bacterial; chaperone ... See more keywords