Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models
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DOI: 10.1371/journal.pone.0216463
Abstract: Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA and H3K9me2 levels are elevated in postmortem brain and peripheral blood cells… read more here.
Keywords: histone methyltransferase; inhibitor bix; bix 01294; gene ... See more keywords