Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7.
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DOI: 10.1016/j.ejmech.2018.03.045
Abstract: Leukotrienes (LTs) and prostaglandin (PG)E2 are enzymatically produced from arachidonic acid and represent highly bioactive lipid mediators with pro-inflammatory functions. Here, we report on novel multi-target inhibitors that potently and dually interfere with 5-lipoxygenase-activating protein… read more here.
Keywords: target inhibitors; inhibitor brp; target; flap inhibitor ... See more keywords