Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer
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DOI: 10.1038/s41598-020-60784-y
Abstract: Abnormal regulation of β-catenin initiates an oncogenic program that serves as a main driver of many cancers. Albeit challenging, β-catenin is an attractive drug target due to its role in maintenance of cancer stem cells… read more here.
Keywords: allosteric inhibitor; inhibitor catenin; catenin; cancer ... See more keywords
Inhibitor of β-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/β-catenin complex
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DOI: 10.3892/or.2017.5962
Abstract: The inhibitor of β-catenin and TCF (ICAT) blocks the binding of TCF to β-catenin and has been demonstrated as a suppressor of the Wnt/β-catenin signaling pathway. It has been reported to exert a different function… read more here.
Keywords: tcf; inhibitor catenin; catenin; cervical cancer ... See more keywords