Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00077
Abstract: The study presented here provides a framework for the discovery of unique inhibitor combinations that target the apoptosis network for cancer therapy. A pair of doxycycline (Dox)-inducible cell lines that specifically report on the ability… read more here.
Keywords: inhibitor; inhibitor combinations; kinase; cancer ... See more keywords
β-lactam/β-lactamase inhibitor combinations: an update.
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DOI: 10.1039/c8md00342d
Abstract: Antibiotic resistance caused by β-lactamase production continues to present a growing challenge to the efficacy of β-lactams and their role as the most important class of clinically used antibiotics. In response to this threat however,… read more here.
Keywords: lactamase inhibitors; class; inhibitor combinations; lactam lactamase ... See more keywords
Broad spectrum of β-lactamase coverage and potent antimicrobial activity of xeruborbactam in combination with meropenem against carbapenemase-producing Enterobacterales, including strains resistant to new β-lactam/β-lactamase inhibitor combinations
Sign Up to like & getrecommendations! Published in 2025 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00533-25
Abstract: ABSTRACT Xeruborbactam is a broad-spectrum boronate-type β-lactamase inhibitor. We aimed to evaluate its activity in combination with meropenem and compare it with other β-lactam/β-lactamase inhibitor combinations against Enterobacterales. The following isolates were screened: (i) an… read more here.
Keywords: lactamase; lactamase inhibitor; lactam lactamase; meropenem ... See more keywords
New β-Lactam–β-Lactamase Inhibitor Combinations
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Microbiology Reviews"
DOI: 10.1128/cmr.00115-20
Abstract: The limited armamentarium against drug-resistant Gram-negative bacilli has led to the development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this review, we summarize their spectrum of in vitro activities, mechanisms of resistance, and pharmacokinetic-pharmacodynamic… read more here.
Keywords: inhibitor combinations; lactam lactamase; lactamase inhibitor; drug ... See more keywords
Efficacy and safety of novel carbapenem–β-lactamase inhibitor combinations: Results from phase II and III trials
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.925662
Abstract: Objectives The addition of novel β-lactamase inhibitors to carbapenems restores the activity against multidrug-resistant Gram-negative bacteria. The aim of this study was to summarize the evidence on the efficacy and safety of novel carbapenem–β-lactamase inhibitor… read more here.
Keywords: novel carbapenem; lactamase inhibitor; carbapenem lactamase; inhibitor combinations ... See more keywords
Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2024.1210313
Abstract: Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options. The purposes of this study were to evaluate the in vitro antibacterial activity of… read more here.
Keywords: lactamase; combination; lactamase inhibitor; lactam lactamase ... See more keywords
Revisiting the Checkerboard to Inform Development of β-Lactam/β-Lactamase Inhibitor Combinations
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DOI: 10.3390/antibiotics13040337
Abstract: A two-dimensional “checkerboard” array employing systematic titration (e.g., serial two-fold dilutions) is a well-established in vitro method for exploring the antibacterial effects of novel drug combinations. Minimum inhibitory concentrations (MICs) on the checkerboard are isoeffective… read more here.
Keywords: lactamase; lactamase inhibitor; lactam lactamase; checkerboard ... See more keywords