Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.
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DOI: 10.1016/j.chembiol.2017.12.014
Abstract: Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Available inhibitors target Smoothened (Smo), which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smo are urgently needed.… read more here.
Keywords: inhibitor cytoplasmic; dynein; novel inhibitor; cytoplasmic dynein ... See more keywords