Inhibitor Discovery by Convolution ABPP.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6439-0_4
Abstract: Activity-based protein profiling (ABPP) has emerged as a powerful proteomic approach to study the active proteins in their native environment by using chemical probes that label active site residues in proteins. Traditionally, ABPP is classified… read more here.
Keywords: convolution abpp; inhibitor discovery; abpp; discovery convolution ... See more keywords
Enabling the hypothesis-driven prioritization of ligand candidates in big databases: Screenlamp and its application to GPCR inhibitor discovery for invasive species control
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-018-0100-7
Abstract: While the advantage of screening vast databases of molecules to cover greater molecular diversity is often mentioned, in reality, only a few studies have been published demonstrating inhibitor discovery by screening more than a million… read more here.
Keywords: species control; invasive species; hypothesis driven; discovery ... See more keywords
Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24244428
Abstract: As protein–protein interactions (PPIs) are highly involved in most cellular processes, the discovery of PPI inhibitors that mimic the structure of the natural protein partners is a promising strategy toward the discovery of PPI inhibitors.… read more here.
Keywords: protein; virtual screening; inhibitor discovery; protein protein ... See more keywords