Upregulation of inhibitor of DNA binding 1 and 3 is important for efficient thermogenic response in human adipocytes
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DOI: 10.1038/s41598-024-79634-2
Abstract: Brown and beige adipocytes can be activated by β-adrenergic agonist via cAMP-dependent signaling. Performing RNA-sequencing analysis in human cervical area-derived adipocytes, we found that dibutyryl-cAMP, which can mimic in vivo stimulation of browning and thermogenesis,… read more here.
Keywords: thermogenic response; dna binding; inhibitor dna; efficient thermogenic ... See more keywords
Differentiation of stem cells isolated from rat skeletal muscles towards cardiomyocytes: The effect of an inhibitor of DNA methylation 5-azacytidine
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DOI: 10.1134/s1062359017040021
Abstract: The effects of the inhibitor of DNA methylation 5-azacytidine on stem (satellite) cells isolated from fetal and definitive skeletal muscles of rats lead to the expression of marker genes of cardiomyogenesis (Gata4, Nkx2.5, connexin-43, n-cadherin,… read more here.
Keywords: methylation azacytidine; skeletal muscles; differentiation; cells isolated ... See more keywords
Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis
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DOI: 10.3389/fimmu.2022.934624
Abstract: Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, proliferation and activation… read more here.
Keywords: stress; dna; dna binding; binding proteins ... See more keywords
The Recombinant Inhibitor of DNA Binding Id2 Forms Multimeric Structures via the Helix-Loop-Helix Domain and the Nuclear Export Signal
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DOI: 10.3390/ijms19041105
Abstract: The inhibitor of DNA binding and cell differentiation 2 (Id2) is a helix-loop-helix (HLH) protein that acts as negative dominant regulator of basic-HLH transcription factors during development and in cancer. The structural properties of Id2… read more here.
Keywords: loop helix; helix loop; helix; dna binding ... See more keywords