Synthesis of rigidified shikimic acid derivatives by ring-closing metathesis to imprint inhibitor efficacy against shikimate kinase enzyme
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DOI: 10.1039/c9qo00562e
Abstract: The rigidification of the high-energy conformation of shikimic acid was used to enhance inhibitor efficacy against shikimate kinase enzyme, an attractive target for antibiotic drug discovery. read more here.
Keywords: shikimic acid; inhibitor efficacy; kinase enzyme; efficacy shikimate ... See more keywords
Effect of Bruton tyrosine kinase inhibitor on efficacy of adjuvanted recombinant hepatitis B and zoster vaccines
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DOI: 10.1182/blood.2020008758
Abstract: Publisher's Note: There is a Blood Commentary on this article in this issue. read more here.
Keywords: inhibitor efficacy; effect bruton; efficacy adjuvanted; kinase inhibitor ... See more keywords
Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide
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DOI: 10.3390/ijms21113895
Abstract: BRCA1/2 variants are prognostic biomarkers for hereditary breast and/or ovarian cancer (HBOC) syndrome and predictive biomarkers for PARP inhibition. In this study, we benchmarked the classification of BRCA1/2 variants from patients with HBOC-related cancer using… read more here.
Keywords: inhibitor efficacy; brca1 variants; brca1; efficacy ... See more keywords