Effect of confounding factors on a phospho-flow assay of ribosomal S6 protein for therapeutic drug monitoring of the mTOR-inhibitor everolimus in heart transplanted patients
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DOI: 10.1080/1354750x.2016.1210676
Abstract: Abstract Context: Several assays of monitoring immune cell function have been developed to enhance therapeutic drug monitoring. Objective: An in vitro-validated whole-blood assay of phosphorylated ribosomal protein S6 (pS6RP) was evaluated for confounders to monitor… read more here.
Keywords: inhibitor everolimus; mtor inhibitor; phospho flow; therapeutic drug ... See more keywords
Effects of mTOR inhibitor, everolimus, on proliferation, autophagy and temozolomide sensitivity of glioma cells
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DOI: 10.4314/tjpr.v19i1.12
Abstract: Purpose: To study the effect of the mTOR inhibitor, everolimus, on glioma cell proliferation, autophagy, and drug sensitivity to temozolomide (TMZ).Methods: Human glioma cell lines were cultured in vitro, and the effects of different concentrations… read more here.
Keywords: glioma; inhibitor everolimus; proliferation autophagy; proliferation ... See more keywords