Abstract 6441: Discovery of ARID1A loss as a patient biomarker for NXP800 - A developmental activator of the integrated stress response (ISR) and inhibitor of the HSF1 pathway in ovarian cancer
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DOI: 10.1158/1538-7445.am2024-6441
Abstract: Background. HSF1 helps cancer cells cope with multiple stresses caused by oncogene activation. Methods. See details below. Results. We discovered the bisamide NXP800 as an inhibitor of HSF1-mediated transcription through phenotypic screening and med chem… read more here.
Keywords: cancer; mutant cells; atf4; inhibitor hsf1 ... See more keywords