Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles
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DOI: 10.1021/acs.jmedchem.1c01807
Abstract: When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity… read more here.
Keywords: cox inhibitor; inhibitor hybrids; fluconazole cox; class ... See more keywords