Differences in the sensitivity of classically and alternatively activated macrophages to TAK1 inhibitor-induced necroptosis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02623-7
Abstract: Controlling the balance of pro-inflammatory M1 versus anti-inflammatory M2 macrophages may have paramount therapeutic benefit in cardiovascular diseases, infections, cancer and chronic inflammation. The targeted depletion of different macrophage populations provides a therapeutic option to… read more here.
Keywords: inhibitor induced; inhibitor; induced necroptosis; sensitivity ... See more keywords
Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain
Sign Up to like & getrecommendations! Published in 2017 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-017-4559-z
Abstract: PurposeAromatase inhibitor (AI)-induced joint symptoms negatively impact drug adherence and quality of life in breast cancer survivors. Mechanisms underlying symptoms may include inflammation. It is hypothesized that n − 3 polyunsaturated fatty acids (PUFAs) have… read more here.
Keywords: inhibitor induced; placebo controlled; fatty acids; cancer ... See more keywords
Nivolumab dose escalation triggered immune checkpoint inhibitor-induced colitis after 147 weeks of prolonged stable use in a patient with lung cancer: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Journal of Gastroenterology"
DOI: 10.1007/s12328-021-01542-z
Abstract: A 56-year-old man with advanced lung adenocarcinoma presented to the emergency department with a 6-day history of diarrhea. He was treated for lung cancer with nivolumab 3 mg/kg (144 mg/body) every 2 weeks (Q2W), followed… read more here.
Keywords: immune checkpoint; inhibitor induced; lung cancer; checkpoint inhibitor ... See more keywords
Immune checkpoint inhibitor-induced encephalitis with dostarlimab in two patients: Case series
Sign Up to like & getrecommendations! Published in 2021 at "eNeurologicalSci"
DOI: 10.1016/j.ensci.2021.100356
Abstract: Abstract Immune checkpoint inhibitors (ICIs) are being used increasingly in the treatment of several cancers and have been associated with neurological complications including immune checkpoint inhibitor-induced encephalitis (ICI-iE). We present two cases of ICI-iE with… read more here.
Keywords: immune checkpoint; inhibitor induced; dostarlimab; checkpoint ... See more keywords
Histological Comparison of TNF-α Inhibitor-Induced Psoriasis and Psoriasis Vulgaris.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2020.01.006
Abstract: BACKGROUND Tumor necrosis factor-α inhibitor-induced psoriasis (TNFI-psoriasis) is a paradoxical reaction characterized by development of a psoriasiform rash that mimics idiopathic psoriasis subtypes both clinically and histologically. Few studies have investigated histologic features of TNFI-induced… read more here.
Keywords: inhibitor induced; induced psoriasis; tnfi psoriasis; idiopathic psoriasis ... See more keywords
Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
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DOI: 10.1038/ncomms15981
Abstract: Mutations in homologous recombination (HR) genes BRCA1 and BRCA2 predispose to tumorigenesis. HR-deficient cancers are hypersensitive to Poly (ADP ribose)-polymerase (PARP) inhibitors, but can acquire resistance and relapse. Mechanistic understanding how PARP inhibition induces cytotoxicity… read more here.
Keywords: inhibitor induced; inhibitor; deficient cancer; parp inhibitor ... See more keywords
Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220182
Abstract: Vascular endothelial growth factor antagonism with angiogenesis inhibitors in cancer patients induces a "preeclampsia-like" syndrome including hypertension, proteinuria and elevated endothelin (ET)-1. Cyclo-oxygenase (COX) inhibition with aspirin is known to prevent the onset of preeclampsia… read more here.
Keywords: induced hypertension; inhibitor induced; angiogenesis; angiogenesis inhibitor ... See more keywords
EGFR inhibitor-induced folliculitis decalvans: a case series and management guidelines.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer drugs"
DOI: 10.1097/cad.0000000000001494
Abstract: Epidermal growth factor receptor (EGFR) is one of therapeutic targets in oncology for solid tumors originating from epithelial tissue, such as non-small-cell lung carcinoma (NSCLC) and breast cancer. EGFR inhibitors used in cancer treatment may… read more here.
Keywords: egfr inhibitor; inhibitor induced; induced folliculitis; folliculitis decalvans ... See more keywords
Immune checkpoint inhibitor-induced myocarditis with myasthenia gravis overlap syndrome: A case report and literature review
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DOI: 10.1097/md.0000000000032240
Abstract: Rationale: The therapeutic value of immune checkpoint inhibitors (ICIs) in a variety of tumors has been found and recognized, and although ICIs have improved the prognosis of many patients with advanced tumors, these drugs sometimes… read more here.
Keywords: checkpoint inhibitor; immune checkpoint; inhibitor induced; report ... See more keywords
ACE inhibitor induced intestinal angioedema
Sign Up to like & getrecommendations! Published in 2022 at "Anz Journal of Surgery"
DOI: 10.1111/ans.17575
Abstract: A 44-year-old Caucasian female presented to an Emergency Department (ED) of a large metropolitan hospital with a one-day history of severe abdominal pain after commencing oral perindopril the day prior. Her medical history included hypertension… read more here.
Keywords: induced intestinal; history; ace inhibitor; inhibitor induced ... See more keywords
Immune checkpoint inhibitor‐induced Type 1 diabetes: a systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "Diabetic Medicine"
DOI: 10.1111/dme.14050
Abstract: To conduct a systematic review and meta‐analysis to understand the timing and factors associated with anti‐programmed cell death protein‐1 (PD‐1)/anti‐programmed cell death protein‐1 ligand (PD‐L1) inhibitor‐induced Type 1 diabetes. read more here.
Keywords: inhibitor induced; review meta; systematic review; type diabetes ... See more keywords