The Nedd8‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma
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DOI: 10.1111/cpr.12536
Abstract: The present study aimed to reveal expression status of the neddylation enzymes in HNSCC and to elucidate the anticancer efficacy and the underlying mechanisms of inhibiting neddylation pathway. read more here.
Keywords: inhibitor mln4924; enzyme inhibitor; tak 924; nedd8 activating ... See more keywords
Neddylation inhibitor MLN4924 induces G2 cell cycle arrest, DNA damage and sensitizes esophageal squamous cell carcinoma cells to cisplatin.
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DOI: 10.3892/ol.2017.7616
Abstract: Inhibiting the protein neddylation pathway using the NEDD8-activating enzyme inhibitor MLN4924 represents an attractive anticancer strategy having been demonstrated to exhibit promising anticancer efficacy and with tolerable levels of toxicity; however, the mechanism by which… read more here.
Keywords: inhibitor; inhibitor mln4924; squamous cell; mln4924 ... See more keywords