Selinexor, selective inhibitor of nuclear export: Unselective bullet for blood cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Blood reviews"
DOI: 10.1016/j.blre.2020.100758
Abstract: Exportin 1 (XPO1), also known as chromosome maintenance 1 protein (CRM1), is the main transporter for hundreds of proteins like tumor suppressors, growth regulatory factors, oncoprotein mRNAs and others. Its upregulation leads to the inactivation… read more here.
Keywords: export; selective inhibitor; nuclear export; selinexor selective ... See more keywords
In silico drug design of inhibitor of nuclear factor kappa B kinase subunit beta inhibitors from 2-acylamino-3-aminothienopyridines based on quantitative structure-activity relationships and molecular docking
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.12.021
Abstract: Inhibitor of nuclear factor kappa B kinase subunit beta (IKK-β), a specific regulator of nuclear factor-κB (NF-κB), is considered a valid target to design novel candidate drugs to treat rheumatoid arthritis and various cancers. In… read more here.
Keywords: factor kappa; structure; inhibitor nuclear; factor ... See more keywords
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00613
Abstract: The small molecule gibberellin JRA-003 was identified as an inhibitor of the NF-kB (nuclear kappa-light-chain-enhancer of activated B cells) pathway. Here we find that JRA-003 binds to and significantly inhibits the nuclear translocation of pathway-activating… read more here.
Keywords: inhibitor nuclear; nuclear translocation; gibberellin jra; jra 003 ... See more keywords
Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc01245b
Abstract: Inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) is a key regulator of the cannonical NF-κB pathway. IKKβ has been validated as a drug target for pathological conditions, which include chronic inflammatory diseases and… read more here.
Keywords: kinase; kappa kinase; factor kappa; inhibitor nuclear ... See more keywords
High uric acid induced hippocampal mitochondrial dysfunction and cognitive impairment involving intramitochondrial NF-κB inhibitor α/nuclear factor-κB pathway
Sign Up to like & getrecommendations! Published in 2022 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001762
Abstract: Objectives Epidemiological research has indicated that hyperuricemia may impair cognitive ability; however, the underlying mechanisms remain unclear. The present study thus investigated the possible mechanism underlying hyperuricemia-related cognitive impairment. Methods Using hyperuricemic rats and high… read more here.
Keywords: inhibitor nuclear; high uric; cognitive impairment; hippocampal mitochondrial ... See more keywords
The expression of inhibitor of nuclear factor kappa-B kinase epsilon (IKKe) in human aortic aneurysm.
Sign Up to like & getrecommendations! Published in 2017 at "Folia morphologica"
DOI: 10.5603/fm.a2017.0016
Abstract: BACKGROUND Aortic aneurysm (AA) is one of the most common causes of sudden death among elderly people. Although AA can be detected by non-invasive imaging techniques, there are no pharmacological treatments currently available to prevent… read more here.
Keywords: ikke; group; aortic aneurysm; expression ... See more keywords