Prodrug Strategies to Improve the Solubility of HCV NS5A Inhibitor Pibrentasvir (ABT-530).
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DOI: 10.1021/acs.jmedchem.0c00956
Abstract: A research program to discover solubilizing prodrugs of HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen via an oxymethyl linkage… read more here.
Keywords: inhibitor pibrentasvir; prodrug; ns5a inhibitor; hcv ns5a ... See more keywords