Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice.
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DOI: 10.1016/j.bbrc.2018.09.100
Abstract: Pathological cardiac hypertrophy is the main risk factor for heart diseases. The ubiquitin-proteasome system (UPS) is the major intracellular protein degradation system involved in the development of cardiac hypertrophic remodeling. Ubiquitin-activating enzyme E1, a key… read more here.
Keywords: pyr; hypertrophic remodeling; inhibitor pyr; uba1 inhibitor ... See more keywords