The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure
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DOI: 10.1002/ehf2.12895
Abstract: Excessive activation of Ca/calmodulin‐dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down development of inhibitors for clinical use. We… read more here.
Keywords: heart; calmodulin dependent; heart failure; inhibitor ra608 ... See more keywords